Multiple states are at risk of becoming uninhabitable due to climate change, forcing their populations to flee. While the 1951 Refugee Convention provides the gold standard of international protection, it is only applied to a limited subset of people fleeing their countries, those who suffer persecution, which most people fleeing climate change cannot establish. While many journalists and non-lawyers freely use the term “climate refugees,” governments, and courts, as well as UNHCR and many refugee experts, have excluded most climate refugees (...) from the Convention as a matter of legal interpretation. In our 2015 paper, “Unable to Return in the 1951 Refugee Convention: Stateless Refugees and Climate Change”, we sought to reopen the debate on “climate refugees” by arguing that some climate refugees qualify under the 1951 Convention as it is currently written (even if they are not persecuted): those who are stateless and are unable to return to their country of origin because climate change has rendered it uninhabitable. Our interpretation, however, has been rejected by Goodwin-Gill and McAdam (2021) and by Foster and Lambert (2019), which explicitly responds to our paper. Here, we address and respond to their arguments, and develop a new supplementary one, drawing on the principle of systemic integration, as enshrined in Article 31(3)(c) of the Vienna Convention on the Law of Treaties. (shrink)

What happens when scholars come together to study Buddhist and German Idealist perspectives on mind and representation? We explore this question and reflect on methodological considerations in what is often referred to as "comparative philosophy.".

In this paper, we consider two different attempts to make an end run around the experimentalist challenge to the armchair use of intuitions: one due to Max Deutsch and Herman Cappelen, contending that philosophers do not appeal to intuitions, but rather to arguments, in canonical philosophical texts; the other due to Joshua Knobe, arguing that intuitions are so stable that there is in fact no empirical basis for the experimentalist challenge in the first place. We show that a closer attention (...) to philosophical practices reveal, in turn, that we cannot make sense of these philosophical texts as arguments all the way down; and that our methods are so sensitive to error that even a modest amount of instability is enough to raise deep methodological concerns. (shrink)

Monoclonal antibodies are essential biomedical research and clinical reagents that are produced by companies and research laboratories. The NIAID ImmPort (Immunology Database and Analysis Portal) resource provides a long-term, sustainable data warehouse for immunological data generated by NIAID, DAIT and DMID funded investigators for data archiving and re-use. A variety of immunological data is generated using techniques that rely upon monoclonal antibody reagents, including flow cytometry, immunofluorescence, and ELISA. In order to facilitate querying, integration, and reuse of data, standardized terminology (...) for describing monoclonal antibody reagents and their targets needs to be used for annotating data submitted to ImmPort. (shrink)

The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

Contemporary work on Boethius' Consolation of Philosophy often overlooks a discussion in CP.V.3 of a Peripatetic strategy for dissolving theological fatalism. Boethius’ treatment of this strategy and the lesson it provides about divine foreknowledge requires a reorientation of our understanding of the Consolation text. The result is that it is not foreknowledge nor any other temporally-conditioned knowledge that motivates Boethian concern but divine knowledge simpliciter.

In this paper we present the comparative study by Jonathan Stoltz, about the similarities between Timothy Williamson's epistemology and the Indo-Tibetan epistemological traditions that developed between the eighth and thirteenth centuries, which lie above that for them the knowledge is a kind of mental state as well as a restricted study of the return to metaphysics, a name that refers to the interesting position of authority born of an attempt to overcome his classical and strong Anglo-American analytical roots.

Brought to you by: Crop X editors: Jonathan Alexander Perez, Harmony Smith, Corinne Tendorf, David Turturo, and Derek Rahn Williams. Faculty Advisor: David Turturo; Crop X team included: Chaimae Alehyane, Zachary S. Casey, Suzanna Brinez, Jacob Brown, Elizabeth George, Francisco Javier Muniz Ituarte, Brodey Myers. -/- Credits: Huckabee College of Architecture; Graphic Designers: Studio BLDG (Blossom Liu + Danny Gray); English Editor: Luke Studebaker; Spanish Translator: Jessie Forbes; Printer: Die Keure. Cover Photo: Derek Williams. -/- Generously supported by (...) the Graham Foundation for Advanced Studies in the Fine Arts and the Huckabee College of Architecture, Texas Tech University. (shrink)

Alexander R. Galloway and Jason R. LaRiviére’s article “Compression in Philosophy” seeks to pose François Laruelle’s engagement with metaphysics against Bernard Stiegler’s epistemological rendering of idealism. Identifying Laruelle as the theorist of genericity, through which mankind and the world are identified through an index of “opacity,” the authors argue that Laruelle does away with all deleterious philosophical “data.” Laruelle’s generic immanence is posed against Stiegler’s process of retention and discretization, as Galloway and LaRiviére argue that Stiegler’s philosophy seeks to (...) reveal an enchanted natural world through the development of noesis. By further developing Laruelle and Stiegler’s Marxian projects, I seek to demonstrate the relation between Stiegler's artefaction and “compression” while, simultaneously, I also seek to create further bricolage between Laruelle and Stiegler. I also further elaborate on their distinct engagement(s) with Marx, offering the mold of synthesis as an alternative to compression when considering Stiegler’s work on transindividuation. In turn, this paper seeks to survey some of the contemporary theorists drawing from Stiegler (Yuk Hui, Al-exander Wilson and Daniel Ross) and Laruelle (Anne-Françoise Schmidt, Gilles Grelet, Ray Brassier, Katerina Kolozova, John Ó Maoilearca and Jonathan Fardy) to examine political discourse regarding the posthuman and non-human, with a particular interest in Kolozova’s unified theory of standard philosophy and Capital. (shrink)

Was Swift correct that “reasoning will never make a man correct an ill opinion, which by reasoning he never acquired” (Letter to a Young Gentleman)? If so, what recourse is there to change attitudes especially among those who continue to fervently believe unjustified claims and act upon them in a way that affects other people? I will answer the first question with a qualified yes, and the second I will follow Swift’s implicit proposal to rely upon humor, satire, playful ridicule, (...) and especially irony to unsettle the certainties of those who have not appealed to reason or epistemic justification to maintain their cherished opinions. In the bulk of the chapter, I will then assess what sort of irony Swift employs: is his irony primarily a trope in the service of a particular idea? Or is he truly Socratic in his irony, the sort Kierkegaard admired that transcends the mere rhetorical device and can be viewed as a stance on life in general? The answer to the latter question, in typical Aristotelian fashion, will be yes and no. My account of Socratic Irony will be informed primarily by the works of Alexander Nehemas, Jorge Portilla, and Jonathan Lear’s interpretation of Kierkegaard on Socrates’ irony. (shrink)

REPRODUÇÃO EM NOVILHAS LEITEIRAS -/- INTRODUÇÃO -/- O principal objetivo da criação de substitutos em gado leiteiro é produzir uma novilha que tenha seu parto aos dois anos de idade (23 a 25 meses) e com um peso de 550 a 580 kg. O manejo reprodutivo das novilhas começa quando estas atingem 14 ou 15 meses de idade e um peso de 350 a 370 kg. A produção de novilhas deve ser suficiente para substituir as vacas descartadas anualmente (25 a (...) 35%), e para contribuir com o crescimento do rebanho. Espera-se que em um gado leiteiro deva haver uma população de animais de reposição, desde um dia de vida até à fase de novilha ao parto, correspondendo pelo menos a 70 % do total das vacas (figura 1). -/- Figura 1: A meta do programa de produção de substitutos ou fêmeas de reposição consiste em uma novilha que chegue ao seu primeiro parto aos 24 ou 25 meses de idade, entre um peso de 550 a 580 kg. Elaborado pelo autor. -/- A produção de novilhas depende basicamente de três fatores: da fertilidade das vacas, ou seja, do número de bezerras nascidas anualmente; da mortalidade durante a criação e desenvolvimento; e da eficiência reprodutiva das novilhas. O manejo reprodutivo moderno das novilhas é orientado para a utilização da inseminação artificial, seja em um estro natural ou sincronizado. As novilhas representam a população animal geneticamente mais avançada no rebanho, portanto, o mérito genético de suas crias obtidas por inseminação é maior do que o das crias das vacas adultas. Além disso, as crias das novilhas obtidas mediante a inseminação aceleram o avanço genético, uma vez que contribuem com uma proporção maior de substituições do rebanho em comparação com as crias das vacas de outras faixas etárias. Além disso, as novilhas são as fêmeas mais férteis do rebanho (porcentagem de concepção: 60 a 70% vs 30 a 40% em vacas), pelo que o custo do sêmen por gestação é menor em comparação com as vacas adultas, o que permite investir em melhores touros e em sêmen sexado. -/- 1. PUBERDADE -/- A puberdade é definida como a fase de desenvolvimento em que a fêmea apresenta o seu primeiro estro fértil. Regularmente as novilhas leiteiras, sob condições ótimas de manejo, chegam à puberdade entre 11 e 12 meses de idade, ou seja, antes de alavancar o peso recomendado para receber o primeiro serviço. Vale salientar que as novilhas podem ficar gestantes após a puberdade; no entanto, isto não é conveniente porque ainda não completou-se o seu desenvolvimento. Se ficarem gestantes nos primeiros ciclos estrais, as novilhas poderiam chegar ao parto com pouco desenvolvimento físico, o que provocaria distocias e baixa produção de leite (figura 2). A ativação do sistema neuroendócrino para que a bezerra atinja a puberdade é regulada principalmente pelo estado nutricional (condição corporal). A transição do anestro pré-puberal à ciclicidade puberal coincide com um aumento da condição corporal e das concentrações de insulina, IGF-I e leptina. Estes hormônios agem como sinais metabólicos no hipotálamo e hipófise que modificam a frequência de secreção das gonadotropinas, resultando na maturação folicular e ovulação. O atraso em relação à puberdade está diretamente relacionado com deficiências na alimentação; esta condição verifica-se em criações pouco tecnificadas, principalmente de pequenos e médios produtores. As novilhas que já atingiram o peso para receber o primeiro serviço e não apresentaram estro, devem ser examinadas por via retal para excluir possíveis anormalidades do desenvolvimento, tais como freemartinismo ou hipoplasia genital. -/- Figura 2: O fator mais importante que determina a puberdade é a nutrição. Bezerras bem alimentadas apresentam ciclos estrais aos 11 meses de idade e devem ser inseminadas aos 14 ou 15 meses de idade, com um peso de 350 a 370 kg. Acervo pessoal do autor. -/- 2. DETECÇÃO DE ESTRO E INSEMINAÇÃO ARTIFICIAL -/- A baixa eficiência na detecção de estros é o problema que mais afeta a eficiência reprodutiva das novilhas. De acordo com a duração do estro (8 a 18 horas), a observação das novilhas em períodos de 30 minutos durante a manhã e à tarde, permite detectar em estro até 70% das fêmeas, enquanto a observação contínua (24 horas) aumenta a eficiência na detecção até 95% (figuras 3 e 4). No manejo tradicional dos rebanhos leiteiros, as novilhas recebem pouca atenção por parte dos trabalhadores, o que resulta em baixa eficiência na detecção de estros (50 a 60%). Em diferença das vacas adultas em lactação, as novilhas estão menos expostas a fatores que diminuem a expressão do estro, portanto, com uma rotina de observação, de pelo menos duas horas na manhã (6h a 8h da manhã) e duas horas pela tarde até a noite (17h da tarde a 19h da noite), pode-se detectar até 90% das fêmeas no estro (figura 5). -/- Figura 3: O fator que mais influencia a idade ao primeiro parto é a baixa eficiência na detecção de estros, pelo que é recomendável a observação de estros com pessoal qualificado, em períodos de pelo menos duas horas pela manhã e duas à tarde. Acervo pessoal do autor. -/- Figura 4: Com a observação contínua é possível alcançar de 90 a 95% de eficiência na detecção de estros. Acervo pessoal do autor. -/- Figura 5: A inseminação deve ser realizada durante o período de receptividade sexual. Com boa eficiência na detecção de estros, a inseminação pode ser praticada no programa AM-PM e PM-AM, ou em apenas um turno de inseminação pela manhã (10:00), com bons resultados. -/- 3. TAXA DE PRENHEZ -/- O melhor indicador de eficiência reprodutiva é a taxa de prenhez. Este indicador refere-se à proporção de animais gestantes do total elegível para inseminação, num período equivalente a um ciclo estral. Como já se descreveu no trabalho Fisiologia do Estro e do Serviço na Reprodução Bovina, este indicador considera a eficiência na detecção de estros e a porcentagem de concepção, e reflete com maior objetividade a eficácia do manejo reprodutivo. Este parâmetro pode ser melhorado através de um aumento da proporção de novilhas detectadas em estro, o que se obtém aumentando o tempo de observação e aplicando técnicas de sincronização do estro (figura 6). -/- 4. INSEMINAÇÃO DE NOVILHAS COM SÊMEN SEXADO -/- A utilização de sêmen sexado é uma boa opção para a produção de novilhas de reposição. Com a nova tecnologia disponível para a separação de espermatozoides com o cromossomo x, é possível alcançar até 90% de crias fêmeas; no entanto, o processo de separação de espermatozoides tem baixa eficiência, o que limita o número de espermatozoides por palheta. As palhetas de inseminação com sêmen sexado contém de dois a três milhões de espermatozoides (doses de sêmen não sexado têm de 20 a 30 milhões). De acordo com os dados de fertilidade de gados comerciais, as novilhas inseminadas com sêmen sexado mostram de 10 a 20% menor concepção que novilhas inseminadas com sêmen não sexado, o que desencoraja o seu uso. Causas de baixa fertilidade não são conhecidas, no entanto, estão associadas com a menor concentração espermática e com alguns danos nos espermatozoides provocados pelo processo de separação. No entanto, o uso de sêmen sexado é uma opção viável para aumentar a produção de novilhas no rebanho, e com o melhoramento dos processos de separação espermática em pouco tempo se converterá em uma prática de rotina nos estábulos (figura 7). -/- Figura 6: Uma técnica que aumenta a eficiência na detecção dos estros consiste em pintar a região da grupa. Quando esta pintura desaparece ou se nota que as novilhas estão "talhadas", devem ser apalpadas via retal para determinar se existem sinais genitais de estro. Acervo pessoal do autor. -/- Figura 7: As novilhas são as fêmeas mais férteis do rebanho, por isso o custo do sêmen por gestação é menor em comparação com as vacas adultas, o que permite investir em melhores touros e em sêmen sexado. Acervo pessoal do autor. 5. MONTA DIRIGIDA -/- A monta dirigida ou direta é uma opção prática e eficaz para emprenhar as novilhas. Neste sistema se introduz um touro com um grupo de novilhas, para que ele se encarregue de encontrar as fêmeas em estro e proceder a monta. Em rebanhos comerciais, o ideal é a utilização de um touro para 25 fêmeas. No entanto, com este manejo perde-se a oportunidade de utilizar a inseminação artificial e, com isso, a possibilidade de melhoria genética. -/- 6. PROGRAMAS DE SINCRONIZAÇÃO DE ESTROS -/- Os tratamentos para sincronizar o estro das novilhas possuem os mesmos fundamentos que os utilizados nas vacas. -/- 6.1 Prostaglandina F2a -/- A PGF2α é utilizada para a sincronização de estros em grupos de novilhas, e também é utilizada para a indução do estro individualmente, nas fêmeas que são examinadas por via retal e têm um corpo lúteo. A resposta dos animais tratados é variável; em novilhas pode-se alcançar até 95% de animais em estro. O tempo de manifestação do estro após a injeção é de 48 a 120 horas. -/- 6.1.1 Dupla injeção de PGF2a -/- Além da sincronização dos animais selecionados pela presença de um corpo lúteo diagnosticado por palpação retal, existem dois programas que não incluem a palpação retal. Por exemplo, na segunda-feira, ou no dia preferido, injeta-se PGF2α em todas as novilhas que se deseja inseminar. Cerca de 50% das novilhas manifestarão estro nas próximas 48 a 120 horas. As fêmeas que não mostrarem estro receberão uma segunda injeção na segunda-feira seguinte (intervalo de sete dias). As que apresentaram estro com a primeira injeção teriam um corpo lúteo nesse momento, enquanto as que não o manifestaram estavam em estro ou em metaestro; assim, ao repetir o tratamento sete dias depois, estas últimas novilhas teriam um corpo lúteo e responderiam à PGF2α (figura 8). No outro programa, é administrada duas doses de PGF2α com 11 dias de separação/intervalo. As novilhas podem ser inseminadas no estro observado, após qualquer uma das duas injeções. Este programa oferece uma boa sincroniza- ção após a segunda injeção e é o programa de escolha na sincronização das novilhas receptoras de embriões (figura 9). -/- Figura 8: Sincronização do estro com dupla injeção de PGF2a com 7 dias de diferença/intervalo. Elaborado pelo autor. -/- Figura 9: Sincronização do estro com dupla injeção de PGF2a com 11 dias de diferença/intervalo. Elaborado pelo autor. -/- 6.2 Progestágenos -/- Existe um tratamento que consiste na inserção, na parte externa da orelha, de um implante que contém norgestomet, que permanece na região auricular por nove dias. Além disso, o tratamento é complementado com a injeção intramuscular de valerato de estradiol e norgestomet, no momento da colocação do implante. O tempo de apresentação do estro a partir da remoção do implante é de 48 a 72 horas e a proporção de animais em estro muitas vezes se torna maior do que 80%. Outro tratamento é baseado na inserção intravaginal de dispositivos de liberação de progesterona. O dispositivo pode ser utilizado durante 12 dias ou o período de exposição pode ser encurtado, desde que seja acompanhado da injeção de uma dose luteolítica de PGF2α, um dia antes ou no momento da remoção do dispositivo. A fertilidade global conseguida após o serviço no estro sincronizado é similar à obtida no estro natural; porém, algumas novilhas são menos férteis, o que está associado com alterações no desenvolvimento folicular e alterações na relação temporal entre o estro e a ovulação. Observou-se que o tratamento com implantes de norgestomet combinados com a injeção de valerato de estradiol pode induzir comportamento estral em animais que não estão ciclando normalmente. Isso ocorre porque os níveis de estradiol, administrados no primeiro dia, persistem até o momento da remoção do implante. Assim, ao remover a fonte do progestágeno e ao haver concentrações altas de estradiol se desencadeia o estro, o qual em novilhas anéstricas não é acompanhado de ovulação, enquanto que em novilhas ciclando se altera a relação temporal entre o estro, pico pré-ovulatório de LH e ovulação. Bons resultados são alcançados quando o valerato de estradiol não é administrado e é substituído por uma injeção de PGF2α no momento da remoção do implante. Outro fator que tem sido associado com baixa fertilidade é o dia do ciclo em que o tratamento começa. Observou-se que quando coincide com a presença de um corpo lúteo (diestro), a porcentagem de concepção é maior do que quando não há um corpo lúteo (proestro). Isto ocorre porque a concentração sérica do progestágeno, por si só, não é capaz de suprimir a secreção pulsátil de LH, o que faz com que o folículo dominante presente no momento de iniciar o tratamento não sofra atresia e persista até o dia da retirada do progestágeno, convertendo-se no folículo ovulatório. Com isso, o folículo já envelheceu e o ovócito já sofreu alterações que reduzem o seu potencial para desenvolver um embrião viável. Quando o tratamento coincide com a presença de um corpo lúteo, a secreção de LH é efetivamente suprimida devido ao efeito aditivo da progesterona secretada pelo corpo lúteo e do progestágeno exógeno, inserido na vaca, o que provoca a reposição folicular. Em condições de campo, a seleção das vacas pela presença de um corpo lúteo antes de iniciar o tratamento com progestágenos é impraticável, uma vez que não é possível visualizá-lo, além disso essa prática/seleção não faria sentido, já que seria mais fácil tratar estes animais com dose ou doses de PGF2α. Atualmente existem tratamentos para eliminar folículos dominantes e promover uma nova onda folicular. -/- 6.3 Progestágenos orais -/- O acetato de melengestrol (MGA) é um progestágeno administrado por via oral. Em fêmeas bovinas é utilizado para melhorar a eficiência alimentar nos currais de engorda, o que se consegue através da inibição da apresentação do estro. Como todos os progestágenos, o MGA inibe a secreção de LH, eliminando assim a maturação do folículo e a ovulação. Após a remoção do MGA, o folículo dominante termina o seu desenvolvimento e as fêmeas apresentam estro em forma sincronizada. A dose de MGA por novilha é de 0,5 a 1 mg por dia, em tratamentos que variam de 9 a 14 dias. A apresentação comercial de MGA contém 0,22 mg do hormônio por 1 g do produto. O MGA pode ser facilmente misturado com qualquer concentrado ou grão moído. Após o último dia de tratamento, o estro se apresenta de dois a seis dias. O intervalo de remoção do MGA ao estro é mais longo quando comparado com outros progestágenos. Isto deve-se ao tempo de remoção do MGA, uma vez que enquanto um implante ou dispositivo intravaginal é removido abruptamente, o MGA pode continuar a ser absorvido enquanto é removido do trato gastrointestinal. Com tratamentos de 14 dias podem-se obter porcentagens de concepção menores em comparação com o estro natural, o que se deve em grande parte à ovulação de folículos persistentes. Um tratamento eficaz, que também melhora a fertilidade, consiste na administração de MGA durante 14 dias, seguido de uma injeção de PGF2α 15 ou 17 dias após a remoção do progestágeno. Com este programa, uma alta proporção de fêmeas teriam um corpo lúteo no momento da injeção da PGF2α e apresentariam estro com boa sincronização. Outro tratamento eficaz consiste na administração do MGA durante nove dias, mais uma dose de PGF2α ao nono dia; com este programa também se obtêm bons resultados em sincronização do estro e fertilidade. Este tratamento foi avaliado com novilhas holandesas e a porcentagem de fêmeas sincronizadas é elevada (95%). A porcentagem de concepção é semelhante à obtida no estro natural. Estes resultados são comparáveis aos obtidos com outros programas, como implantes de norgestomet ou dispositivos intravaginais de liberação de progesterona, mas com um custo significativamente menor (figura 10). -/- 6.4 Sincronização da ovulação e inseminação em tempo fixo -/- Em contraste com o observado em vacas em lactação, a resposta das novilhas aos programas de sincronização da ovulação e inseminação a tempo fixo é deficiente, o que se reflete em porcentagens de concepção de 20 a 35% menores que as novilhas inseminadas no estro natural. A causa desta resposta está relacionada com diferenças no desenvolvimento folicular; assim, nas novilhas o tempo de desenvolvimento do folículo dominante é mais rápido e o tempo de domínio é mais curto do que nas vacas em lactação. Desta forma, o folículo da onda folicular sincronizada com a injeção de GnRH sofre atresia antes da injeção de PGF2α, de tal forma que quando se induz a ovulação com a segunda injeção de GnRH, as novilhas têm folículos em diferentes estádios de desenvolvimento, o que provoca assincronia entre a ovulação e a inseminação artificial. -/- Figura 10: Programa de sincronização do estro com Acetato de Melengestrol (MGA). Elaborado pelo autor. -/- 7. MANEJO DO ANESTRO -/- Uma vez que as novilhas atingem a puberdade, apresentam ciclos estrais em intervalos de 21 dias que só são interrompidos pela gestação ou por alguma patologia. O anestro patológico é raro em novilhas; no entanto, surgem casos de piometra e cistos luteinizados, que são tratados com uma dose de PGF2α. Também se observam anormalidades de desenvolvimen- to, tais como freemartinismo e hipoplasia genital, patologias que não têm tratamento; somente 8% das novilhas freemartin são férteis. O anestro funcional (as novilhas manifestam estro, mas não são detectadas) é frequen- te e está diretamente relacionado com a eficiência na detecção de estros. As novilhas com idade e peso para se integrarem no programa reprodutivo e não apresentarem sinais de estro devem ser examinadas retalmente para diagnosticar a causa do anestro. Se, durante a palpação retal, as novilhas tiverem um corpo lúteo são tratadas nesse momento com PGF2α, os animais sem corpo lúteo podem receber uma injeção de PGF2α, sete dias depois. Este programa sincroniza o estro e aumenta a probabilidade de o detectar (figura 11). -/- Figura 11: As novilhas com idade e peso para se integrarem no programa reprodutivo e não mostrarem sinais de estro devem ser verificadas via retal para diagnosticar a causa do anestro. Arquivo pessoal do autor. -/- 8. MANEJO DA NOVILHA INFÉRTIL -/- A fertilidade das vacas leiteiras diminuiu nos últimos 30 anos, enquanto a fertilidade das novilhas não se alterou; após a primeira inseminação, entre 60 e 70% das novilhas emprenham. O objetivo do programa reprodutivo é conseguir que 90% das novilhas gestem nos primeiros três serviços. Desta forma, esta proporção de animais daria à luz antes dos 25 meses de idade. É comum que 10% das novilhas se transformem em animais repetidores, ou seja, novilhas com mais de três serviços inférteis. A causa da falha na concepção de novilhas deve-se principalmente à morte embrionária precoce. Uma causa importante da falha na concepção das novilhas repetidoras são as patologias adquiridas no aparelho reprodutivo; é comum encontrar aderências ovarianas e salpingite. Provavelmente, esses problemas são consequência de alguma infecção adquirida durante a criação. Diversos tratamentos hormonais têm sido testados para resolver o problema de infertilidade em novilhas repetidoras e os resultados obtidos ainda são deficientes. Como estes tratamentos não apresentam resultados consistentes, a melhor forma de mitigar o problema de infertilidade nas novilhas é melhorando as práticas de inseminação, ou seja, o momento da inseminação, o manejo do sêmen e a técnica de inseminação empregada. Além disso, a melhor técnica para aumentar a proporção de novilhas prenhes no rebanho é aumentar a eficiência da detecção de estros. -/- 9. RESUMO -/- As novilhas devem parir aos dois anos de idade (23 a 25 meses). O peso ao parto deve ser de 550 a 580 kg. O manejo reprodutivo começa aos 14 ou 15 meses de idade, com um peso de 350 a 370 kg. As palhetas de sêmen sexado contêm de 2 a 3 milhões de espermatozoides. As doses de sêmen não sexado contêm de 20 a 30 milhões de espermatozoides. A porcentagem de concepção das novilhas inseminadas com sêmen sexado é 10 a 20% menor do que com sêmen não sexado. Com sêmen sexado se obtém entre 90 e 95% de fêmeas. A porcentagem de concepção com programas de IATF é de 20 a 35% menor que nas novilhas inseminadas no estro natural. Cerca de 90% das novilhas devem ficar prenhes nos primeiros três serviços. Devem ser produzidas novilhas para substituir as vacas que são descartadas anualmen- te (25 a 35%). Espera-se que um gado leiteiro tenha ao dispor uma população de animais de reposição, desde um dia de vida até a etapa de novilha ao parto, correspondente a, pelo menos, 70 % do total das vacas. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- AUAD, Alexander Machado et al. Manual de bovinocultura de leite. Brasília: LK Editora, 2010. BRICKELL, J. S.; MCGOWAN, M. M.; WATHES, D. C. Effect of management factors and blood metabolites during the rearing period on growth in dairy heifers on UK farms. Domestic animal endocrinology, v. 36, n. 2, p. 67-81, 2009. DE VRIES, A. et al. Exploring the impact of sexed semen on the structure of the dairy industry. Journal of Dairy Science, v. 91, n. 2, p. 847-856, 2008. Fertilidade em Vacas Leiteiras: Fisiologia e Manejo. Fisiologia do Estro e do Serviço na Reprodução Bovina. FERREIRA, A. M. Manejo reprodutivo de bovinos leiteiros: práticas corretas e incorretas, casos reais, perguntas e respostas. Edição do autor, Juiz de Fora, 2012. FERREIRA, A. de M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns (causas e tratamentos). Juiz de Fora: Minas Gerais–Brasil, p. 422, 2010. GALINA, Carlos; VALENCIA, Javier. Reproducción de los animales domésticos. 2006. GONÇALVES, J. N. Manual do produtor de leite. Viçosa, MG: Aprenda Fácil, 2012. HEINRICHS, A. J. Raising dairy replacements to meet the needs of the 21st century. Journal of dairy science, v. 76, n. 10, p. 3179-3187, 1993. HOFFMAN, P. C. Optimum body size of Holstein replacement heifers. Journal of Animal Science, v. 75, n. 3, p. 836-845, 1997. NEIVA, R. S. Criação eficiente de bezerros e novilhas. Lavras: Autor, 2013. NEIVA, Rogério Santoro. Produção de bovinos leiteiros. Lavras: UFLA, 1998. PEREIRA, E. S. et al. Novilhas leiteiras. Graphiti Gráfica e Editora LTDA, Fortaleza, Ceará, 2010. CARVALHO, B. C. Manejo reprodutivo de novilhas leiteiras. In. SENAR. Curso de reprodução e genética em bovinocultura de leite. Coronel Pacheco: Senar, 2021. YOUNGQUIST, Robert S.; THRELFALL, W. R. Large animal theriogenology. 2007. (shrink)

Aristotle says that ὑπαρχειν has as many senses as ‘to be true’ (PrA. , A, 36, 48b2-9) and as many ways as there are different categories. (PrA., A, 37, 49a6-9) This may mean that for every ‘is’ there is a ὑπαρχειν. Τhe reason is that Aristotle uses ὑπαρχειν in converse direction of ‘is’. The equal statement of ‘A is B’ with ὑπαρχειν is ‘B ὑπαρχει to A.’ Allen Bāck points to the difference between the use of the verb with dative (...) case and its use with a subject alone in Greek language. When it is used with the dative, it retains its basic meaning, that is, ‘be already present’ or ‘exist really.’ ‘So to say that P belongs to S is to say that P exists in S, or, if you like, that P has its being in S.’ He believes that Aristotle uses this construction to insist that primary substances alone are the fundamental being and all other things only are ‘in’ substances. Thus, when the verb is used with the dative, it expresses dependent substance relation. But when it is used with a subject alone, e.g. in ‘S ὑπάρχει,’ it expresses that the subject really exists. (OI., 17a24 and 17b2) Thus, while it is the subject which is said to be the predicate, it is the predicate which ὑπάρχει to the subject. The formula of ‘τὸ Α ὑπάρχει τῷ Β’ is equivalent to ‘τὸ Β ἐστι Α.’ He uses the word for the predication of a category on substance (e.g. Met., α, 993b24-25; Met., Z, 1029a15-16; Cat., 5, 3b24-25), the predication of secondary substance on primary substance (e.g. Met., Z, 1038b21-23; Cat., 5, 2a14-19), the predication of primary substance on nothing else but itself (e.g. Met., Z, 1040b23-24), the belonging of a verb to the subject, the belonging of axioms to a single science (Met., 1005a22-23) , the belonging of PNC to all things that are (Met., IV, 3) , in the sense of really existing (Cael. 297b22, Met., 1041b4. Cf. B503, 125-126) or merely in the sense of the predication of a predicate on a subject (e.g. OI., I, 5, 17a22-24) and especially and much more repeatedly than anywhere else in his discussion of syllogism. (e.g. PrA., A, 36, 48a40-b2; PrA., B, 22, 67b28-30; PrA., A, 24a26-28) It is also used in some related senses like mere belonging (e.g. Met., A, 989a10-14; K, 1060a9-10) or to be there. (So., B, 5, 417b23-26) Some of its derived forms are also used by Aristotle. For example, ἐνυπαρχον in the sense of the thing that is ‘in’ something; (e.g. Met., A, 991a13-16; Met., Z, 1038b29-33 and 1039a3-5) ὑπερέχον in the sense of that which contains and ὑπερεχόμενον in the sense of that which is contained in something else. (e.g. Met., Δ, 1020b26-28) In a sense, the extent of the application of ὑπαρχειν is wider than ‘is’ since it is not restricted to the nominative form in which ‘is’ is used but is applicable to other cases as well: ‘For ‘That does not belong to this’ does not always mean that ‘This is not that’ but sometimes that ‘this is not of that’ or ‘for that.’ (PsA., A, 36, 48b28-33) Allen Bāck (B503, 124) points that in the Prior Analytics Aristotle uses ‘ὑπάρχει τῷ’ and ‘κατηγορεῖσθαι κατά’ interchangeably. (e.g. at 25b37-26a4) Referring to its converse construction in respect of μετέχει (if A belongs to B, then B participates in A) as a probable reason that it may have Platonist foundations. But the question is: why does Aristotle uses this construction (B belongs to A) instead of simply saying A is B? Alexander of Aphrodisias (Apr 54.21-29) wonders why Aristotle had to adhere to such artificial language, entirely unnatural for ordinary speakers of Greek. As Jonathan Barnes points out, all the three formulas of ‘τὸ Α ὑπάρχει τῷ Β,’ ‘τὸ Α κατηγορεῖται κατὰ τοῦ Β’ and ‘τὸ Α λέγεται κατὰ τοῦ Β’ are artificial in the sense that no Greek who wanted to say that pleasure was good would normally have expressed himself by way of any of them.’ Bāck thinks Aristotle may have used it ‘to stress the primacy of primary substances as the ultimate subjects.’ He also mentions the probability that it may be to emphasize that the terms are being coupled in predication without any existence condition, a suggestion he is not himself inclined with. Robin Smith notes for Aristotle that ‘belonging to’ construction is wider than ‘predicated of’ construction because it can be used for cases that cannot easily be treated as categorical sentences. While predication is restricted to cases in which the subject term is in the nominative case, belonging can indicate, as he quotes Mignucci (480-481), ‘any possible grammatical construction for a predicative relation’ . (shrink)

Existing research suggests that people's judgments of actual causation can be influenced by the degree to which they regard certain events as normal. We develop an explanation for this phenomenon that draws on standard tools from the literature on graphical causal models and, in particular, on the idea of probabilistic sampling. Using these tools, we propose a new measure of actual causal strength. This measure accurately captures three effects of normality on causal judgment that have been observed in existing studies. (...) More importantly, the measure predicts a new effect ("abnormal deflation"). Two studies show that people's judgments do, in fact, show this new effect. Taken together, the patterns of people's causal judgments thereby provide support for the proposed explanation. (shrink)

According to Paul Boghossian and others, inference is subject to the taking condition: it necessarily involves the thinker taking his premises to support his conclusion, and drawing the conclusion because of that fact. Boghossian argues that this condition vindicates the idea that inference is an expression of agency, and that it has several other important implications too. However, we argue in this paper that the taking condition should be rejected. The condition gives rise to several serious prima facie problems and (...) the reasons which have been offered in favour of it fail to convince. (shrink)

ABSTRACTRecent debate over the semantics and pragmatics of epistemic modals has focused on intuitions about cross-contextual truth-value assessments. In this paper, we advocate a different approach to evaluating theories of epistemic modals. Our strategy focuses on judgments of the incompatibility of two different epistemic possibility claims, or two different truth value assessments of a single epistemic possibility claim. We subject the predictions of existing theories to empirical scrutiny, and argue that existing contextualist and relativist theories are unable to account for (...) the full pattern of observed judgments. As a way of illustrating the theoretical upshot of these results, we conclude by developing a novel theory of epistemic modals that is able to predict the results. (shrink)

Twenty years have passed since Gould and Lewontin published their critique of ‘the adaptationist program’ – the tendency of some evolutionary biologists to assume, rather than demonstrate, the operation of natural selection. After the ‘Spandrels paper’, evolutionists were more careful about producing just-so stories based on selection, and paid more attention to a panoply of other processes. Then came reactions against the excesses of the anti-adaptationist movement, which ranged from a complete dismissal of Gould and Lewontin’s contribution to a positive (...) call to overcome the problems. We now have an excellent opportunity for finally affirming a more balanced and pluralistic approach to the study of evolutionary biology. (shrink)

This paper examines visual representation from a distinctive, interdisciplinary perspective that draws on ethics, visual studies and critical race theory. Suggests ways to clarify complex issues of representational ethics in marketing communications and marketing representations, suggesting an analysis that makes identity creation central to societal marketing concerns. Analyzes representations of the exotic Other in disparate marketing campaigns, drawing upon tourist promotions, advertisements, and mundane objects in material culture. Moreover, music is an important force in marketing communication: visual representations in music (...) promotions are also explored as data for inquiry. Offers an alternative to phenomenologically based approaches in marketing and consumer research scholarship that use consumer responses to generate data. Contributes additional insight into societal marketing and places global marketing processes within the intersection of ethics, aesthetics and representation. (shrink)

This paper is about teaching elementary logic to blind or visually impaired students. The targeted audience are teachers who all of sudden have a blind or visually impaired student in their introduction to logic class, find limited help from disability centers in their institution, and have no idea what to do. We provide simple techniques that allow direct communication between a teacher and a visually impaired student. We show how the use of what is known as Polish notation simplifies communication, (...) and pedagogically is a great notation for a Braille reader. (shrink)

The works of the later Wittgenstein resonate with aspects of the pragmatist tradition in American philosophy. Davidson’s work is similarly informed. We argue that because of their association with the pragmatist tradition, their work can be put to use by philosophers interested in social justice issues, including, for example, feminism, and critical race theory. Philosophers concerned with social justice continue to struggle between the extremes of an untenable foundationalism and a radical relativism. Given their holistic understanding of knowledge, meaning and (...) communication, the work of Wittgenstein and Davidson is particularly suited to dissolving the foundationalist/relativist dichotomy. We explore how this and other features of their work facilitates philosophy for social change. (shrink)

Methadone maintenance therapy is a cost-effective, evidence-based treatment for heroin dependence. In the USA, a majority of heroin-dependent offenders are forced to detox from methadone when incarcerated. Recent research published in The Lancet has demonstrated the negative health and economic outcomes associated with such policies. Methadone Continuation Versus Forced Withdrawal on Incarceration in a Combined US Prison and Jail: A Randomised, Open Label Trial. The Lancet, 386, 350–359). This novel evidence raises questions as to the justification for current policies of (...) forced detox in American prisons. Opponents of methadone provision in prisons might offer arguments from retributivism, resource allocation and curative effectiveness to justify their position. This article contends that these arguments do not stand up to ethical scrutiny. In light of this, we hold that American policymakers should reform criminal justice policies to allow the initiation and continuation of methadone treatment in correctional settings. This would be consistent with both international recommendations and the example set by a number of other Western countries. (shrink)

Using two decades worth of experimental philosophy (aka x-phi), Edouard Machery argues in Philosophy within its Proper Bounds (OUP, 2017) that philosophers’ use of the “method of cases” is unreliable because it has a strong tendency to elicit different intuitive responses from non-philosophers. And because, as Machery argues, appealing to such cases is usually the only way for philosophers to acquire the kind of knowledge they seek, an extensive philosophical skepticism follows. I argue that Machery’s “Unreliability” argument fails because, once (...) its premises are percisified, they are either self-defeating or without justification. This is a significant result because Machery’s arguments are the most widely cited and discussed x-phi arguments for philosophical skepticism and many hold that Machery provides the most empirically informed, convincing, and thus best case for this kind of skepticism. So, if my arguments are sound, then the best x-phi argument for philosophical skepticism fails. I further argue that this result provides strong reason to believe the more general conclusion that “negative” x-phi is likely doomed: x-phi likely can never support a substantive philosophical skepticism. Ultimately, I argue for the broad conclusion that all empirically minded arguments for philosophical skepticism are likely to fail for the same reasons that Machery’s does, i.e. they are (likely) self-defeating. (shrink)

Nature-based solutions (NbS) have in recent years occupied a central position in conservation and climate discussions among both scientists and policy makers. NbS generally refer to a set of strategies which use nature, or natural objects, to address societal (human) issues while simultaneously supporting the broader environment. This paper examines the concept of NbS to determine whether it is a useful and well-motivated category to guide future climate and conservation efforts. I argue that NbS may in fact be a valuable (...) contribution to environmental thought and policy, but not for the reasons that they are typically thought to be. Specifically: while we have reason to doubt that NbS should be prioritized over other environmental strategies on the grounds that they are uniquely environmentally-friendly or supportive of biodiversity, they may nevertheless have an advantage insofar as they play a vital aesthetic role in developing a healthier relationship between humans and the nonhuman world. (shrink)

An influential heuristic for thinking about climate adaptation asserts that “natural” adaptation strategies are the best ones. This heuristic has been roundly criticized but is difficult to dislodge in the absence of an alternative. We introduce a new heuristic that assesses adaptation strategies by looking at their maturity, power, and commitment. Maturity is the extent to which we understand an adaptation strategy’s effects. Power is the size of the effect an adaptation strategy will have. Commitment is the degree to which (...) an adaptation strategy is difficult to test or reverse. (shrink)

This chapter surveys a few of the central questions about philosophical perspectives on the ethics of belief, focusing especially on (1) questions about whether doxastic involuntarism is consistent with the normative approach to epistemology characteristic of any ethics of belief; (2) the status and interpretation of William Clifford's famous injunction against belief on "insufficient" evidence, and broader questions about the role of negative versus positive doxastic norms; (3) whether norms governing belief are distinctively epistemic norms, or are instead moral or (...) practical ones; and (4) how moral and political questions about belief bear on epistemic norms, including a discussion of doxastic wronging, racist beliefs, skepticism and rape culture, and epistemic partiality—whether, for instance, friendship requires beliefs that violate epistemic norms. (shrink)

Abstract: In The Imaginary Jean-Paul Sartre makes what will strike many as an implausibly strong claim, namely that perception and imagination are incompatible kinds of experience - I call this the exclusion claim. This paper offers a reconstruction of Sartre’s exclusion claim. First, it frames the claim in terms of cross-modal attention distribution, such that it is not possible to simultaneously attend to what one is imagining and what one is perceiving. However, this leaves it open that a subject can (...) simultaneously imagine and perceive on the condition that either the perceived or imagined objects are not attended to. While this is a philosophically plausible position it fails to do justice to Sartre’s intended position, which suggests a more radical exclusion between perception and imagination. In light of this section 3 develops a supplementary argument to remove one of the possible configurations of attention that the ban on divided attention leaves in place by arguing that the objects of imagining must be attended to, which follows from Sartre’s characterisation of imagination as spontaneous. The resulting exclusion is as follows: attentive perception excludes imagination (and vice versa), given that the latter is necessarily attentive, but attentive imagination can co-occur with non-attentive or background perception (in this sense the exclusion is asymmetric in a way that Sartre fails to recognise). In concluding I detail how from this exclusion we get an important consequence – which Sartre wants the exclusion claim to have – namely that it rules out an imagination-based solution to the problem of perceptual presence. (shrink)

Post-Traumatic Stress Disorder is a mental health condition in which the experience of a traumatic event causes a series of psychiatric and behavioral symptoms such as hypervigilance, insomnia, irritability, aggression, constricted affect, and self-destructive behavior. This paper investigates two case studies to argue that the experience of PTSD is not restricted to humans alone; we have good epistemic reason to hold that some animals can experience genuine PTSD, given our current and best clinical understanding of the disorder in humans. I (...) will use this evidence to argue for two claims. First, because the causal structure of PTSD plausibly requires reference to a traumatic conscious experience in order to explain subsequent behaviors, the fact that animals can have PTSD provides new evidence for animal consciousness. Second, the discovery of PTSD in animals puts pressure on accounts which hold that animal behavior can be fully explained without reference to subjective experience. (shrink)

Deliberative democracy is increasingly criticised as out of touch with the realities of partisan politics. This paper considers the rise of fake and hyperpartisan news as one source of this scepticism. While popular accounts often blame such content on citizens’ political biases and motivated reasoning, I survey the empirical evidence and argue that it does not support strong claims about the inability of citizens to live up to deliberative ideals. Instead, much of this research is shown to support the deliberative (...) capacities of citizens and points to their potential in helping to reduce the spread of false and misleading content. (shrink)

This paper focuses on an underexplored challenge in infinite ethics. On realistic assumptions, if our universe is infinite, every nomologically possible history is actual and nothing we ever do makes a difference to the moral quality of the world as a whole. Call this thought Every History. This paper unpacks Every History and explores some of its ethical implications. Specifically, I argue that if Every History is true and the universe turns out to be infinite (1) our lives are globally (...) insignificant, (2) moral principles enjoining the promotion of value need to be given an appropriately scope-restricted interpretation, and (3) impersonal consequentialism faces a serious challenge. (shrink)

Is the brain really a computer? In particular, is our intelligence a computational achievement: is it because our brains are computers that we get on in the world as well as we do? In this paper I will evaluate an ambitious new argument to the contrary, developed in Landgrebe and Smith (2021a, 2022). Landgrebe and Smith begin with the fact that many dynamical systems in the world are difficult or impossible to model accurately (inter alia, because it is intractable to (...) find exact solutions to the differential equations that describe them—meaning we have to approximate—but at the same time they are such that small differences in starting conditions lead to big differences in final conditions, thwarting accurate approximation). Yet we manage to survive and thrive in a world full of such systems. Landgrebe and Smith argue from these premises that it is not because our brains are computers that we get on as well as we do: instead it is because of the various ways that we dynamically couple with such systems, these couplings themselves impossible to model well enough to emulate in silico. Landgrebe and Smith thus defend a dynamical systems model in the lineage of Gibson (1979), Van Gelder (1995), and Thompson (2007), though their focus is on decisively refuting the computationalist alternatives rather than developing the positive account. Here I will defend the claim that human intelligence is genuinely computational (and that whole brain emulation and others forms of AGI may be possible) against this argument. (shrink)

Hermeneutical injustice is being unjustly prevented from making sense of one’s experiences, identity, or circumstances and/or communicating about them. The literature focusses almost exclusively on whether people have access to adequate conceptual resources. In this paper, we discuss a different kind of hermeneutical struggle caused by stigma. We argue that in some cases of hermeneutic injustice people have access to hermeneutical resources apt to understand their identity but reject employing these due to the stigma attached to the identity. We begin (...) with a reinterpretation of one of the cases discussed in the literature, Edmund White’s novel A Boy’s Own Story. We argue that in this case hermeneutic resources are available but are rejected due to the stigma attached to homosexuality. We then present two analogous kinds of cases: alcohol addiction and being the victim of intimate partner violence. Here, too, hermeneutic injustice occurs because of stigma attached to an identity rather than unavailability of resources. We close by suggesting that these cases may, additionally, involve the wrong of Tightlacing: by meddling with their self-conception, stigma can manipulate individuals into a view of themselves that licenses inappropriate demands on them and makes them complicit in an erasure of their identities. (shrink)

In evolutionary medicine and other related fields, the concept of evolutionary mismatch is used to explain phenomena whereby traits reduce in adaptive value and eventually become maladaptive as the environment changes. This article argues that there is a similar problem of persistent adaptivity—what has been called the problem of evolutionary novelty—and it introduces the concept of mismatch resistance in order to explain phenomena whereby traits retain their adaptive value in novel environments that are radically different from the organisms’ environment of (...) evolutionary adaptedness (EEA). The possible role of variability selection in the evolution of mismatch-resistant traits is discussed, and it is suggested that mismatch resistance provides a useful tool for making progress on certain issues related to evolutionary theory, such as the modularity debate, cases of adaptivity outside of organisms’ ancestral environment, and the viability of naturalism as an overarching philosophical framework for understanding the natural world. (shrink)

In this paper, I explore the Guam Department of Education's (GDOE) decolonization efforts and the potential role of Philosophy for Children (P4C) as a strategic tool for its advancement. I begin with a discussion of Guam's colonial context and its implications for contemporary education on the island. While the GDOE's current attempts to decolonize Guam's public education emphasize the need for an "official body of knowledge," many CHamoru scholars and activists have argued that it is not enough. This paper agrees (...) that such content-based reforms are insufficient and advocates for a more nuanced approach to education through P4C. Drawing on the P4C literature and decolonial education, I argue that while P4C alone may not bring about structural change, its pedagogical framework offers a promising alternative when adapted to indigenous contexts. The paper proposes that P4C can serve as a "Trojan Horse" within public schools, fostering decolonial acts of resurgence by elevating indigenous knowledge, welcoming indigenous masters, and empowering CHamoru students within a Westernized educational setting. (shrink)

Traditionally, epistemology has been individualistic. Evidentialism fits squarely in this individualistic tradition. According to evidentialism, it is the mental states of the subject alone that fully determine what she is justified in believing. More recently, epistemology has become more and more social, moving away from this individualistic paradigm. Social epistemology examines the social nature of knowledge and rationality and thus engages in projects that are a departure from more traditional epistemology. It might be thought that social epistemology has no room (...) for the evidentialist. In this paper, I argue that one can be an evidentialist as well as a thoroughgoing social epistemologist. In section 1, I explain individualistic epistemology and evidentialism. In section 2, I highlight some of the central projects of social epistemology. In section 3, I argue that none of the projects in section 2 are in conflict with evidentialism and that many can be fruitfully pursued from within an evidentialist framework. In sections 4 – 7, I examine and respond to two challenges to a successful evidentialist social epistemology. The first, inspired by Goldberg (2010), claims that evidentialism is ill-equipped to handle the insights regarding the epistemic importance of what is happening in the minds of others. The second, inspired by Lackey (2018), claims that evidentialism is unable to address a form of epistemic injustice. I show that both challenges can be met by the evidentialist. (shrink)

Who should decide who gets to say what on online social media platforms like Facebook, Twitter, and YouTube? American legal scholars have often thought that the private owners of these platforms should decide, in part because such an arrangement is thought to serve valuable free speech interests. This standard view has come under pressure with the enactment of statutes like Texas House Bill 20, which forbids certain platforms from “censoring” user content based on viewpoint. Such efforts to regulate the speech (...) policies of online platforms have been challenged for undermining the editorial speech rights of these platforms and allowing the proliferation of hate speech. This Article develops a democratic theory of free speech, according to which one of the most important reasons for protecting robust free speech rights is that free speech can contribute not only to democratic elections but to a democratic culture more generally. To achieve robust cultural democracy, a community’s speech environment must enable people not only to rationally persuade one another about matters of public importance and convey mutual respect to one another as political equals but also allow people to influence each other in a less articulate and rational manner—to “democratically vibe” with one another. This theory yields a qualified normative defense of government regulation of the speech policies of large social media platforms that can help to realize cultural democracy, suggesting that First Amendment doctrine should focus to a greater extent on protecting the speech rights of platform users, rather than platform owners. Although far from a ringing endorsement of H.B. 20 or S.B. 7072, this Article suggests that First Amendment law should be friendlier to state regulation of platform speech than many critics have thought. (shrink)

For several decades scientists and philosophers studying how the mind works have debated the issue of modularity. Their main disagreements concern the massive modularity hypothesis, according to which all (or most) of our cognitive mechanisms are modular in nature. Pietraszewski and Wertz (2022) have recently suggested that the modularity debate is based on a confusion about the levels of analysis at which the mind can be explained. This article argues that their position suffers from three major problems: (1) the argument (...) is unsound, with untrue premises; (2) it glosses over important empirical issues; and (3) the guidelines it offers are not sufficient for avoiding future confusions. As these criticisms are developed, this article will provide a way of making sense of the modularity debate—with an eye for what really is at stake both conceptually and empirically—and, by identifying a false assumption often shared by proponents and opponents of the massive modularity hypothesis alike, it will sketch out some guidelines for moving the debate forward. (shrink)

Born to secular Jewish parents and raised in Camden, New Jersey, Andrea Dworkin became a radical second-wave feminist. By Dworkin’s own account, her work is informed by a series of negative personal experiences, including sexual assault at age nine, again by doctors at the Women's House of Detention in New York in 1965, work as a prostitute, and marriage to a battering husband whom she left in 1971. While Dworkin self-identified as a lesbian, since 1974 she lived with a gay (...) male partner, writer John Stoltenberg, whom she married in 1998. Understandably, the main theme of Dworkin's work is male violence against women. This violence is a defining feature of our male-supremacist culture, in which rape, prostitution, and pornography are inevitable expressions of gender norms. Dworkin's writings are primarily aimed at social change rather than intellectualizing. She describes her first book as "a political action where revolution is the goal". What one finds in her writings is not so much philosophical theorizing as calls to action. Thus it is difficult to summarize the abstract theory to which she is committed and from which she draws arguments against the sexism she finds in our culture. What is clear is her desire to eliminate binary concepts of gender and their oppressive effects. In particular, Dworkin urges the destruction of a female gender role that involves masochism, self-hatred, and passivity. She sees male supremacy constructed and reinforced in our culture through the sexist structuring of public institutions and private interactions, locating three crucial foci of male supremacy in action: pornography, sexual intercourse, and rape. These are her central concerns. Her work includes seven monographs, three collections of essays and speeches, a memoir, two novels, and a book of short stories, all of which explore these themes. (shrink)

Jonathan Y. Tsou examines and defends positions on central issues in philosophy of psychiatry. The positions defended assume a naturalistic and realist perspective and are framed against skeptical perspectives on biological psychiatry. Issues addressed include the reality of mental disorders; mechanistic and disease explanations of abnormal behavior; definitions of mental disorder; natural and artificial kinds in psychiatry; biological essentialism and the projectability of psychiatric categories; looping effects and the stability of mental disorders; psychiatric classification; and the validity of the (...) DSM's diagnostic categories. The main argument defended by Tsou is that genuine mental disorders are biological kinds with harmful effects. This argument opposes the dogma that mental disorders are necessarily diseases that result from biological dysfunction. Tsou contends that the broader ideal of biological kinds offers a more promising and empirically ascertainable naturalistic standard for assessing the reality of mental disorders and the validity of psychiatric categories. (shrink)

This paper presents a novel understanding of the notion of calculability. In Gricean frameworks, calculability is defined in terms of how speakers can infer an implicature. The relevant inferences must e.g. be based on maxims of conversation or cooperation principles. Meanwhile, I suggest to define calculability in terms of when, or under which conditions, speakers can infer an implicature. An implicature is calculable if hearers can infer its existence even supposing that the implicature is not semantically encoded. This approach avoids (...) familiar challenges, including recently prominent challenges from pragmatic particularism. (shrink)

Does art have ethical possibilities? Can literature disclose our responsibilityfor other people? This short text aims to unfold some nuances of responsible and irresponsible art as they appear in Emmanuel Levinas's sparse remarks on aesthetics. We examine some common ways of conceiving Levinas's thoughts in literary studies, followed by a closer discussion of his ideas on the possibilities of art in "Reality and Its Shadow" and his late interviews on Vasily Grossman and Sacha Sosno.

Epistemic Courage is a timely and thought-provoking exploration of the ethics of belief, which shows why epistemology is no mere academic abstraction - the question of what to believe couldn't be more urgent. Jonathan Ichikawa argues that a skeptical, negative bias about belief is connected to a conservative bias that reinforces the status quo.

In this paper I examine a recent incarnation of common objection to evidentialism. According to this common objection, evidentialism gives the wrong verdicts in cases where the subject has been irresponsible in inquiry. Sandy Goldberg (2021) has argued that a particularly vivid instance of this problem occurs when an individual violates normative expectations that have been placed on them in their inquiry. Having laid out Goldberg’s case, I argue that the desirable verdicts can be better attained by endorsing evidentialism and (...) supplementing it with an account of robust justification that I have defended elsewhere. (shrink)

Recently, some have attempted to reformulate debates in first-order metaphysics, particularly in the metaphysics of time and modality, for reasons due to Williamson. In this paper, we focus on the ways in which the likes of Cameron, Correia and Rosenkranz, Deasy, Ingram, Tallant, Viebahn, inter alia, have initiated and responded to attempts to capture the core of presentism using a formal, logical machinery. We argue that such attempts are doomed to fail because there is no theoretical core to presentism. There (...) is no single view or family of views that is presentism. (shrink)

Any philosophy of science ought to have something to say about the nature of mathematics, especially an account like constructive empiricism in which mathematical concepts like model and isomorphism play a central role. This thesis is a contribution to the larger project of formulating a constructive empiricist account of mathematics. The philosophy of mathematics developed is fictionalist, with an anti-realist metaphysics. In the thesis, van Fraassen's constructive empiricism is defended and various accounts of mathematics are considered and rejected. Constructive empiricism (...) cannot be realist about abstract objects; it must reject even the realism advocated by otherwise ontologically restrained and epistemologically empiricist indispensability theorists. Indispensability arguments rely on the kind of inference to the best explanation the rejection of which is definitive of constructive empiricism. On the other hand, formalist and logicist anti-realist positions are also shown to be untenable. It is argued that a constructive empiricist philosophy of mathematics must be fictionalist. Borrowing and developing elements from both Philip Kitcher's constructive naturalism and Kendall Walton's theory of fiction, the account of mathematics advanced treats mathematics as a collection of stories told about an ideal agent and mathematical objects as fictions. The account explains what true portions of mathematics are about and why mathematics is useful, even while it is a story about an ideal agent operating in an ideal world; it connects theory and practice in mathematics with human experience of the phenomenal world. At the same time, the make-believe and game-playing aspects of the theory show how we can make sense of mathematics as fiction, as stories, without either undermining that explanation or being forced to accept abstract mathematical objects into our ontology. All of this occurs within the framework that constructive empiricism itself provides the epistemological limitations it mandates, the semantic view of theories, and an emphasis on the pragmatic dimension of our theories, our explanations, and of our relation to the language we use. (shrink)

We are all guided by thousands of norms, but how did our capacity for normative cognition evolve? I propose there is a deep but neglected link between normative cognition and practical skill. In modern humans, complex motor skills and craft skills, such as toolmaking, are guided by internally represented norms of correct performance. Moreover, it is plausible that core components of human normative cognition evolved as a solution to the distinctive problems of transmitting complex motor skills and craft skills, especially (...) skills related to toolmaking, through social learning. If this is correct, the expansion of the normative domain beyond technique to encompass more abstract norms of fairness, reciprocity, ritual and kinship involved the elaboration of a basic platform for the guidance of skilled action by technical norms. This article motivates and defends this “skill hypothesis” for the origin of normative cognition and sets out various ways in which it could be empirically tested. (shrink)

Human neural organoid research is advancing rapidly. As Greely notes in the target article, this progress presents an “onrushing ethical dilemma.” We can’t rule out the possibility that suff...